منابع مشابه
Neuropeptide Y: History and Overview
Neuropeptide Y (NPY) is a 36-amino acid peptide with structural similarities to peptide YY (PYY) and pancreatic polypeptide (PP). NPY, one of the most abundant neuropeptides known, is widely distributed throughout the central and peripheral nervous systems, while PYY and PP are predominantly distributed in the endocrine cells of the intestine and pancreas, respectively. Five NPY receptor subtyp...
متن کاملNeuropeptide Y GERALD
NEUROPEPTIDE Y (NPY) was identified as a neuropeptide that is colocalized and coreleased with the neurotransmitter norepinephrine from sympathetic nerve terminals. In this regard, a large body of research on NPY focused on its role in autonomic physiology and pharmacology as a potentiator of the postsynaptic actions of norepinephrine. However, with the increased understanding of the genes and t...
متن کاملIn Focus Neuropeptide Y
NEUROPEPTIDE Y (NPY) was identified as a neuropeptide that is colocalized and coreleased with the neurotransmitter norepinephrine from sympathetic nerve terminals. In this regard, a large body of research on NPY focused on its role in autonomic physiology and pharmacology as a potentiator of the postsynaptic actions of norepinephrine. However, with the increased understanding of the genes and t...
متن کاملPlasticity of Y1 and Y2 receptors and neuropeptide Y fibers in patients with temporal lobe epilepsy.
Marked expression of neuropeptide Y (NPY) and its Y2 receptors in hippocampal mossy fibers has been reported in animal models of epilepsy. Because NPY can suppress glutamate release by activating presynaptic Y2 receptors, these changes have been proposed as an endogenous protective mechanism. Therefore, we investigated whether similar changes in the NPY system may also take place in human epile...
متن کاملSomatostatin- and neuropeptide Y-synthesizing neurones in the fascia dentata of humans with temporal lobe epilepsy.
We used in situ hybridization techniques to study the distribution of neurones synthesizing somatostatin mRNA and neuropeptide Y mRNA in the hilar region of the hippocampal formation of patients with temporal lobe epilepsy. In the dentate gyrus, somatostatin mRNA- and neuropeptide Y mRNA-synthesizing neurones were found to be exclusively located within the hilar region. Unlike animal models, no...
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ژورنال
عنوان ژورنال: Epilepsy Currents
سال: 2003
ISSN: 1535-7597,1535-7511
DOI: 10.1046/j.1535-7597.2003.03208.x